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As COVID-19 cases continue to rise, researchers have started to look for solutions in an unlikely place - the cannabis plant. Cannabis’ active compounds have a number of properties that make it appealing as a potential adjunct treatment for infections from the novel coronavirus, and recently scientists have begun looking at its potential for
reducing susceptibility to the disease, and even discussed whether it could be used as an
antiviral medication.
CBD has shown serious
anti-inflammatory properties in previous studies, it doesn't create the
disorienting psychotropic effects associated with cannabis’ most common chemical THC, and it has already been
approved by the FDA as safe for children with intractable epilepsy. If successful at reducing inflammation for COVID-19 patients, it could be a safer alternative to other anti-inflammatory options.
Why do researchers believe CBD can help with COVID-19, specifically?
For one thing, the authors explain that previous
research has shown that CBD can reduce a number of pro-inflammatory cytokines including IL-6, the one reduced by other drugs being studied for COVID-19. CBD was also shown to reduce interleukin (IL)-2, IL-1α and β, interferon gamma, inducible protein-10, monocyte chemoattractant protein-1, macrophage inflammatory protein-1α, and tumor necrosis factor-α - all of which are associated with the pathology of severe cases of COVID-19. In addition to reducing these pro-inflammatory cytokines, CBD has also been shown to
increase the production of interferons, a type of signaling protein that activates immune cells and prevents viruses from replicating.
Previous research also supports the idea that CBD can specifically reduce lung inflammation. In an animal
study on asthma, CBD was able to reduce production of proinflammatory cytokine production, actually reducing airway inflammation. In the same study CBD also reduced pulmonary fibrosis - a condition where lung tissue becomes damaged and scarred, thickening lung tissue and making breathing more difficult. This is important, because
COVID-19 can also leave patients with serious pulmonary fibrosis.
Researchers are recommending more research into how cannabis-derived CBD might help treat dangerous lung inflammation from the novel coronavirus. The authors detailed the evidence for how cannabis’ anti-inflammatory powers may help in this month's issue of Brain, Behavior, and Immunity.
www.forbes.com